Triethylamine → 1-Methylethyl 4-{(1R)-1-[(methylsulfonyl)oxy]ethyl}-1-piperidinecarboxylate

Participants

Reaction Steps

1-Methylethyl 4-{(1R)-1-[(methylsulfonyl)oxy]ethyl}-1-piperidinecarboxylate (0.7 g, 100%) was prepared as a light yellow oil from 1-methylethyl 4-[(1R)-1-hydroxyethyl]-1-piperidinecarboxylate (0.5 g, 2.32 mmol), methanesulfonyl chloride (0.22 mL, 2.79 mmol), Et3N (0.49 mL, 3.48 mmol) and CH2Cl2 (30 mL) in a manner similar to Example 150, Step 1. The crude material was used without further purification. 1H NMR (400 MHz, CDCl3): δ 4.88 (septet, 1H, J=6.2 Hz), 4.70-4.55 (m, 1H), 4.30-4.10 (m, 2H), 2.99 (s, 3H), 2.75-2.60 (m, 2H), 1.80-1.60 (m, 3H), 1.38 (d, 3H, J=6.3 Hz), 1.35-1.15 (m, 8H).

Provenance & Evidence