HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-Bromo-1-(methoxymethyl)-2-(methylsulfonyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [4-Bromo-2-(methanesulfonyl)phenyl]methanol | HCID 59251623 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-1-(methoxymethyl)-2-(methylsulfonyl)benzene | HCID 67162100 | — |
Reaction Steps
To a mixture of (4-bromo-2-methansulfonyl-phenyl)-methanol (0.73 g, 2.78 mmol), sodium hydride (0.030 g, 8.4 mmol), and THF (10 mL) was added iodomethane (0.21 mL, 3.36 mmol). After 1 h, the reaction was poured into water (40 mL), diluted in CH2Cl2, and washed with brine (40 mL). The organic layer was dried over (Na2SO4), filtered, concentrated and purified by silica gel column chromatography to give 600 mg of 4-bromo-2-methansulfonyl-1-methoxymethyl-benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536187B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-009dda63e9274e249d3ea5c81a2e6896 |
| Source note | uspto-grants-2013_09 |