Sodium Carbonate → HCID 66673255, compound

HRID 423672Notes

Reaction equation

HRID 423672 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:13]1[N:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]2[CH2:26][CH2:25][N:24]([C:27]([O:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]2)=[CH:15][CH:14]=1.C([O-])([O-])=O.[Na+].[Na+]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.COCCOC>[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:13]2[N:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]3[CH2:22][CH2:23][N:24]([C:27]([O:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH2:25][CH2:26]3)=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 27339594-(Methylthio)phenylboronic acidHCID 866387374-(6-Bromopyridin-3-yloxymethyl)piperidine-1-carboxylic acid isopropyl ester

Product 1

HCID 66673255HCID 66673255, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of [4-(methylthio)phenyl]boronic acid (66 mg, 0.39 mmol), 1-methylethyl 4-{[(6-bromo-3-pyridinyl)oxy]methyl}-1-piperidinecarboxylate (prepared as in Example 81, Step 1, 140 mg, 0.39 mmol), PdCl2(PPh3)2 (50 mg), 2M Na2CO3 (1 mL) and DME (2 mL) was stirred and heated in a microwave at 120° C. for 10 min, cooled to ambient temperature, and the organics were separated. The aqueous phase was washed with EtOAc. The organics were combined, dried over MgSO4, filtered, and the filtrate was concentrated. The crude product was purified by chromatography on a silica gel column using 0 to 50% EtOAc/hexanes to give 140 mg (90%) of 1-methylethyl 4-[({6-[4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate as a white solid. 1H NMR (400 MHz, CDCl3): δ 8.32 (d, 1H, J=2.8 Hz), 7.84 (d, 2H, J=8.5 Hz), 7.60 (d, 1H, J=8.8 Hz), 7.30 (d, 2H, J=8.5 Hz), 7.22 (bs, 1H), 4.90 (septet, 1H, J=6.3 Hz), 4.20 (bs, 2H), 3.87 (d, 2H, J=6.3 Hz), 2.85-2.70 (m, 2H), 2.50 (s, 3H), 2.04-1.94 (m, 1H), 1.90-1.75 (m, 2H), 1.35-1.20 (m, 8H); LRMS (ESI), m/z 401 (M+H).

Workup

  1. temperaturecooled to ambient temperature
  2. customthe organics were separated
  3. washThe aqueous phase was washed with EtOAc
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated
  7. customThe crude product was purified by chromatography on a silica gel column

Sources & evidence

ORD record
ord-0a0effb98a2f453aa3d4f66357bd5ed1
Source dataset
uspto-grants-2012_01
Patent number
US08101634B2

Reaction notes

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