Hydrogen Peroxide → HCID 66672997, compound

Participants

Reaction Steps

The title compound (370 mg, 99%) was prepared as an off-white solid from 1-methylethyl 4-[({6-[4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (prepared as in Example 173, Step 1, 360 mg, 0.9 mmol), 30% H2O2 (aq) (0.612 mL, 5.4 mmol) and 1,1,1,3,3,3-hexafluoro-2-propanol (3 mL) in a manner similar to Example 171, Step 3. 1H NMR (400 MHz, CDCl3): δ 8.50 (d, 1H, J=2.7 Hz), 8.05 (d, 2H, J=8.4 Hz), 7.78-7.71 (m, 3H), 7.45 (dd, 1H, Ja=8.7 Hz, Jb=2.5 Hz), 4.91 (septet, 1H, J=6.2 Hz), 4.21 (bs, 2H), 3.93 (d, 2H, J=6.3 Hz), 2.84-2.72 (m, 5H), 2.09-1.96 (m, 1H), 1.90-1.80 (m, 2H), 1.37-1.20 (m, 8H); LRMS (ESI), m/z 417 (M+H).

Provenance & Evidence