Carbon Dioxide → HCID 24995899, compound

Participants

Reaction Steps

The racemic sulfoxide 1-methylethyl 4-[({6-[4-(methylsulfinyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (Example 173, 370 mg) was subjected to Chiral HPLC [column: Chiralpak AS-H, column mobile phase: 65% CO2: 35% MeOH (1 mL/min), pressure 140 bar, temperature 40° C., 215 nm] analysis and then separation to give two (R and S) enantiomers. The title compound (99 mg) was isolated as an off-white solid with Tr of 7.24 min (second eluting peak). The (S) absolute stereochemistry was assigned by Ab initio VCD analysis.

Provenance & Evidence