Acetone → 6-[2-Fluoro-4-(methylsulfonyl)phenyl]-3-pyridinol

Participants

Reaction Steps

Oxone® (9.05 g, 14.7 mmol) was added to a solution of 6-[2-fluoro-4-(methylthio)phenyl]-3-pyridinol hydrochloride (prepared as in Example 176, Step 1, 2 g, 7.4 mmol) in acetone (45 mL) and water (15 mL) at room temperature. The mixture was stirred at room temperature overnight. The reaction was filtered to remove the solid, and washed by CH2Cl2. The filtrate was brought to pH=7 with 2M Na2CO3 and was extracted with CH2Cl2. The organic extract was washed with brine, dried over Na2SO4, and evaporated to dryness. The residue was treated with a small amount of CH2Cl2 and sonicated, and then the solid was collected by filtration and washed with a small amount of CH2Cl2. The filtrate was evaporated to dryness again, treated with a small amount of CH2Cl2 and sonicated. The resulting solid was collected and washed by a small amount of CH2Cl2. The solids were combined to give 1.35 g (65%) of 6-[2-fluoro-4-(methylsulfonyl)phenyl]-3-pyridinol as a pink solid.

Provenance & Evidence