HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42372Generated: October 25, 2026
Water → 6-Hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one
https://huagongshe.com/reaction/42372
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 6-Chloro-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 66524919 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-Hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 67069008 | — |
Reaction Steps
A mixture of 6-chloro-3-phenyl-1,5-naphthyridin-2(1H)-one (7-1) (1.4 g, 5.61 mmol) and hydrazine hydrate (2 g, 40 mmol) in pyridine (18 mL) was heated under microwave irradiation at 160° C. for 1.5 hours. To the mixture was added Et2O and water, and the resulting solid was collected by filtration to give 6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)one (7-2) as orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536193B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-1743d55a84284d259933a725ef93c5da |
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| Source note | uspto-grants-2013_09 |
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