反应详情

A mixture of 2-(methylsulfanyl-phenylamino-methylene)-malonic acid diethyl ester (27 g, 87 mmol) in 1,2-dichlorobenzene (100 mL) was heated to reflux for 1.5 h. The solvent was removed under reduced pressure and the oily residue was triturated with hexane to afford a pale yellow solid that was purified by preparative HPLC to yield 4-hydroxy-2-methylsulfanyl-quinoline-3-carboxylic acid ethyl ester (8 g, 35%).

1. temperaturewas heated
2. temperatureto reflux for 1.5 h
3. customThe solvent was removed under reduced pressure
4. customthe oily residue was triturated with hexane
5. customto afford a pale yellow solid
6. customthat was purified by preparative HPLC