HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | diethyl N-(3-oxo-1-cyclohexen-1-yl)-aminomethylenemalonate | HCID 12877078 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | HCID 12876362 | 722.7% |
Reaction Steps
A mixture of 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (2.8 g, 1 mmol) and diphenylether (20 mL) was refluxed for 15 min. After cooling, n-hexane (80 mL) was added. The resulting solid was isolated via filtration and recrystallized from methanol to give 4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (1.7 g 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101767B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-d5ab5d0363e441cab274b0438e029ce8 |
| Source note | uspto-grants-2012_01 |