関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Difluoroacetic acid | HCID 9788 | — |
| 反応物 | Ethyl difluoroacetate | HCID 9961 | — |
| 反応物 | 6-Hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 67069008 | — |
| 溶媒 | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| 生成物 | 1-(Difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a][1,5]naphthyridin-7(6H)-one | HCID 67094079 | — |
反応手順
A mixture of 6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)-one (7-2) (21 g, 83 mmol), ethyl difluoroacetate (31 g, 250 mmol), and difluoroacetic acid (200 mg, 2.08 mmol) in DMI (100 mL) was heated under microwave irradiation at 200° C. for 1 h. To the cooled mixture was added water, and the resulting solid was collected by filtration to give 1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (10-1) as pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08536193B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-bb3372ca47a9425ba89b4ac18a1052b0 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
