Potassium Carbonate → HCID 25000074, compound

Participants

Reaction Steps

To a room temperature solution of example 1, (4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, (0.20 g, 0.38 mmol) and potassium carbonate (0.26 g, 1.88 mmol) in tetrahydrofuran (5 mL) was added dropwise propionyl chloride (0.05 mL, 0.56 mmol). The reaction mixture was allowed to stir at room temperature overnight. The crude material was concentrated and purified via prep-TLC (CH2Cl2:2M NH3 in MeOH, 97:3) to afford 0.09 g (42%) of the desired product as a white powder. MS m/z 589.1 (M+H)+; Retention time (LC-MS): 3.68 min.

Provenance & Evidence