反应详情

温度

80 °C

A mixture of 1,1-cyclohexanediacetic anhydride (5.0 g, 27 mmol), pyridine (2.2 mL, 27 mmol), and benzyl alcohol (2.8 mL, 27 mmol) and toluene (5.0 mL, 47 mmol) was stirred at 80° C. overnight. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate and 1 N HCl. The organic layer was washed three times with 1 N HCl and brine. The organic extract was dried over sodium sulfate, filtered, and concentrated to dryness to yield the title compound (7.06 g, 89% yield) as a clear oil. 1H NMR (DMSO-d6, 400 mHz) δ (ppm): 11.96 (s, 1H), 7.32 (m, 5H), 5.03 (s, 2H), 2.52 (s, 2H), 2.34 (s, 2H), 1.40 (m, 10H).

1. temperatureThe reaction mixture was cooled to room temperature
2. custompartitioned between ethyl acetate and 1 N HCl
3. washThe organic layer was washed three times with 1 N HCl and brine
4. extractionThe organic extract
5. dry with materialwas dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated to dryness