反应详情

41.1 g (0.3 mol) of p-aminobenzoic acid and 300 M of acetic acid were put into a 250 M flask to dissolve the p-aminobenzoic acid in the acetic acid, and then 29.4 g (0.3 mol) of maleic anhydride was slowly added thereto at 10° C. to obtain a yellow precipitate. This precipitate was recrystallized with a solution of DMF (dimethylformamide) and ethanol (50:50, w/w) to form an intermediate. The intermediate was treated at 85° C. for 15 minutes using sodium acetate and acetic anhydride, was cooled to room temperature, and was then precipitated in an ice water bath to obtain a precipitate. The obtained precipitate was recrystallized with a solution of ethyl acetate and n-hexane (50:50, w/w) to obtain N-(p-carboxyphenyl)maleimide.

1. customat 10° C. to obtain a yellow precipitate
2. customThis precipitate was recrystallized with a solution of DMF (dimethylformamide) and ethanol (50:50, w/w)
3. customto form an intermediate
4. additionThe intermediate was treated at 85° C. for 15 minutes
5. customwas then precipitated in an ice water bath
6. customto obtain a precipitate
7. customThe obtained precipitate was recrystallized with a solution of ethyl acetate and n-hexane (50:50, w/w)