Tavaborole → An-2718

HRID 424372Notes

Reaction equation

HRID 424372 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH2:9][O:10]COC.FC1C=CC2[B:22](O)[O:21]CC=2C=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[B:22]([OH:21])[O:10][CH2:9][C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 11499245TavaboroleHCID 590246772-Bromo-5-chloro-1-(methoxymethoxymethyl)benzene

Product 1

HCID 11845944An-2718

Procedure

This compound was made from 18d in the same manner as compound 19b: mp 142-144° C. 1H NMR (300 MHz, DMSO-d6) δ (ppm) 4.96 (s, 2H), 7.38 (d, J=7.8 Hz, 1H), 7.49 (s, 1H), 7.71 (d, J=7.8 Hz, 1H), 9.30 (s, 1H); ESI-MS m/z 167 (M−H)−; HPLC purity 99.0%; Anal (C7H6ClO2.0.1H2O)C, H.

Sources & evidence

ORD record
ord-ae588215d655468ba2d4232e2cd23cf3
Source dataset
uspto-grants-2012_01
Patent number
US08106031B2

Reaction notes

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