HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl 4-formylpiperidine-1-carboxylate | HCID 1514430 | — |
| Reactant | Ethyl cysteinate hydrochloride | HCID 2723617 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine | HCID 66679551 | — |
Reaction Steps
4-formyl-piperidine-1-carboxylic acid tert-butyl ester (1.0 eq, 13 mmol) was dissolved under inert conditions in 40 ml toluene. To this solution L-cystein ethylester hydrochloride (1.6 eq, 21 mmol) and triethylamine (1.6 eq, 21 mmol) were added. The mixture was refluxed for 14 h. The generated water was removed with a Dean & Stark trap.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106048B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-3012813bc37f47c393dac5a60a7dbb27 |
| Source note | uspto-grants-2012_01 |