Benzoyl chloride → HCID 178523952, compound

HRID 424410Notes

Reaction equation

HRID 424410 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][NH2:13])=[N:4][N:3]=1.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[N:12][NH:13][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 27937521-Chloro-4-hydrazinophthalazine2×

Product 1

HCID 178523952HCID 178523952, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

2.5 g (4-chloro-phthalazin-1-yl)-hydrazine (compound C1) are suspended in 250 ml toluene and treated with a solution of 1.7 ml benzoic acid chloride in 50 ml toluene at reflux temperature. After 2 h the reaction mixture is cooled to ambient temperature and filtered with suction. The filtrate is concentrated under reduced pressure and the residue is recrystallized from N,N-dimethylformamide to yield 1.2 g of benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide.

Workup

  1. temperatureat reflux temperature
  2. filtrationfiltered with suction
  3. concentrationThe filtrate is concentrated under reduced pressure
  4. customthe residue is recrystallized from N,N-dimethylformamide

Sources & evidence

ORD record
ord-2fb38df105044e3689745026859d1f41
Source dataset
uspto-grants-2012_01
Patent number
US08106047B2

Reaction notes

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