HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (2S)-2-(4-bromophenyl)oxirane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (s)-2-Bromo-1-(4-bromophenyl)ethanol | HCID 11097916 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (2S)-2-(4-bromophenyl)oxirane | HCID 12163514 | 100.5% |
Reaction Steps
Aqueous sodium hydroxide (1M, 400 ml) was added to 2-bromo-(1S)-1-(4-bromophenyl)ethanol (77.0 g) in diethyl ether (400 ml) and stirred at room temperature for 5 hours. The organic layer was separated and water layer was extracted with ether. Combined organic layer was washed with brine and dried over anhydrous sodium sulfate. Removal of the solvent yielded (2S)-2-(4-bromophenyl)oxirane (55.0 g) as a pale brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106045B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-a2eb469c71b94d8f968070d6e48d7265 |
| Source note | uspto-grants-2012_01 |