HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 424460Generated: October 30, 2026
Potassium Carbonate → 1-[(3-Cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine
https://huagongshe.com/reaction/424460
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione | HCID 21088927 | — |
| Reactant | 3-Pyridinecarbonitrile, 2-(chloromethyl)- | HCID 46911834 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[(3-Cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine | HCID 16726544 | — |
Reaction Steps
202 g (0.68 mol) 3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine, 188.5 g (1.36 mol) anhydrous potassium carbonate and 1.68 liters of N-methyl-2-pyrrolidone are placed in the reactor and heated to 70° C. Then 119 g (0.75 mol) 2-chloromethyl-3-cyano-pyridine in 240 ml N-methyl-2-pyrrolidine (NMP) are added dropwise. The contents of the reactor are stirred for 19 hours at 70° C. After the reaction has ended 2.8 liters of water are added to the reaction mixture and it is cooled to 25° C. The product is filtered off, washed with 2 liters of water and dried in the drying cupboard at 70° C. while being rendered inert.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106060B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-90b4fc25571942b19e005ee4a68026a8 |
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| Source note | uspto-grants-2012_01 |
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