Hydrochloric Acid → HCID 178464033, compound

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Reaction Steps

To a stirred solution of N-(4-(2-(diethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide (1.149 g, 3.07 mmol) in MeOH (5 mL) was added 1M HCl in ether (15.35 mL, 15.35 mmol) at room temperature. The mixture was stirred for 5 minutes under argon atmosphere and concentrated to give a yellow solid (1.37 g, quantitative). 1H NMR (DMSO-d6) δ 11.24 (s, 2H), 9.68 (s, 1H), 8.69 (s, 1H), 8.15-8.13 (m, 2H), 7.37-7.34 (m, 1H), 7.12-7.00 (m, 3H), 3.88-3.83 (m, 2H), 3.69-3.66 (m, 2H), 3.17-3.10 (m, 8H), 1.25 (t, J=7.2 Hz, 6H); ESI-MS (m/z, %): 377, 375 (MH+, free base, 58), 278, 276 (100); ESI-HRMS calculated for C19H25N4S2 (MH+, free base), calculated: 375.1671, observed: 375.1667; HPLC: 95% by area.

Provenance & Evidence