Hydrochloric Acid → HCID 178464392, compound

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To a solution of N-(4-(2-(ethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide (131 mg, 0.378 mmol) in methanol (2 mL) was added hydrogen chloride (1M in diethyl ether; 1.134 mL, 1.134 mmol). The resulting mixture was concentrated in vacuo, giving an orange solid, (159 mg, 100%). 1H NMR (DMSO-d6) δ 11.43 (s, 1H), 9.72 (s, 1H), 9.22 (brs, 2H), 8.73 (s, 1H), 8.18-8.12 (m, 2H), 7.38-7.34 (m, 1H), 7.14-7.05 (m, 2H), 6.64-6.60 (m, 1H), 3.70-3.61 (m, 4H), 3.16-3.02 (m, 4H), 2.99-2.88 (m, 2H), 1.21 (t, J=7.2 Hz, 3H); HRMS (C17H23N4S2, MH+, free base): calculated: 347.1358, observed: 347.1346. HPLC purity: 97% by area.

Provenance & Evidence