Hydrochloric Acid → HCID 178478754, compound

Participants

Reaction Steps

To a solution of N-(4-(piperidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)thiophene-2-carboximidamide (210 mg, 0.586 mmol) in methanol (4 mL) was added hydrogen chloride (1 M in diethyl ether; 1.757 mL, 1.757 mmol). The resulting solution was concentrated in vacuo to give a pale yellow solid (252 mg, 100%). 1H NMR (DMSO-d6) δ 11.45 (s, 1H), 9.76 (s, 1H), 9.22 (s, 2H), 8.75 (s, 1H), 7.40-7.34 (m, 1H), 7.13 (d, J=8.1 Hz, 1H), 7.02 (s, 1H), 6.64 (d, J=8.1 Hz, 1H), 4.02-3.92 (m, 1H), 3.46-3.39 (m, 2H), 3.37-3.26 (m, 2H), 3.12-2.91 (m, 4H), 2.15-1.98 (m, 2H), 1.86-1.78 (m, 2H); HRMS (C18H23N4S2, MH+, free base): calculated: 359.1358, observed: 359.1351. HPLC purity: 97% by area.

Provenance & Evidence