Hydrochloric Acid → HCID 178464395, compound

Participants

Reaction Steps

A solution of N-(4-(2-(ethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide (0.142 g, 0.410 mmol) in dry methanol (5 mL) was treated with hydrochloric acid (1M in ether; 2.049 mL, 2.049 mmol) and stirred at room temperature for 1 hour. The reaction was then concentrated to give a yellow solid. 1H-NMR (DMSO-d6) δ 11.22 (brs, 1H) 9.68 (brs, 1H), 9.32 (brs, 2H), 8.69 (brs, 1H), 8.15-8.11 (m, 2H), 7.36 (pseudo t, J=7.2 Hz, 1H), 7.06-6.99 (m, 3H), 3.70-3.60 (overlap with solvent peak, m, 4H), 3.12-3.02 (m, 4H), 3.02-2.93 (m, 2H), 1.23 (t, J=7.2 Hz, 3H).

Provenance & Evidence