3-Bromopentane → HCID 25128637, compound

Participants

Reaction Steps

To 5-(3-(cyclopentyloxy)-4-methoxyphenyl)pyridazin-3-one prepared in Working Example 5, sodium hydride was added and stirred for 1 hour. Then, 3-pentylbromide dissolved in dimethylformamide was added dropwise and stirred for 18 hours. The reaction mixture was poured into ice-cold water and extracted with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous sodium sulfate. The residue that had been filtered and concentrated was purified by flash chromatography to obtain the title compound.

Provenance & Evidence