Trifluoroacetic acid → HCID 57786843, compound

Participants

Reaction Steps

First triethylsilane (1.12 g, 1.54 ml, 9.6 mmol) and then trifluoroacetic acid (5 ml) were added to a solution of {2-[(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-methylamino]-ethoxy}-acetic acid tert-butyl ester (2.48 g, 6.18 mmol) in MC (50 ml) and the mixture was stirred at RT for 5 h. The mixture was then concentrated i. vac., and the residue was taken up repeatedly in toluene and the mixture in each case concentrated again. The crude product was dissolved in EtOAc and the solution was extracted with 5% strength NaHCO3 soln. (3×50 ml). The combined aqueous phases were adjusted to pH 1 with conc. hydrochloric acid and extracted again with EtOAc (3×50 ml). The combined EtOAc phases were dried with Na2SO4 and concentrated i. vac. Yield: 2.41 g (>99%)

Provenance & Evidence