Methanol → HCID 43577519, compound

Participants

Reaction Steps

A 2 M soln. of borane-dimethylsulfide complex in THF (4.96 ml, 9.92 mmol) was added to a soln. of [cyclopropyl-(2,4,6-trichlorobenzenesulfonyl)-amino]-acetic acid (1.77 g, 4.96 mmol) in anhydrous THF (30 ml) and the mixture was stirred for 1 h, while cooling with ice. The reaction mixture was stirred at RT for approx. 18 h, MeOH (2 ml) was then cautiously added and the mixture was concentrated i. vac. MeOH was repeatedly added to the residue and the mixture concentrated i. vac. 5% strength NaHCO3 soln. was added to the crude product, the mixture was extracted with EtOAc and the organic phase was dried with Na2SO4 and concentrated i. vac. Yield: 1.02 g (60%)

Provenance & Evidence