HCID 24739395, compound → HCID 25115991, compound

Participants

Reaction Steps

N,N′-Carbonyldiimidazole (195 mg, 1.2 mmol) was added to a soln. of {2-[(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-methylamino]-ethoxy}-acetic acid (Intermediate C) (346 mg, 1 mmol) in THF (5 ml) and the mixture was stirred at RT for 1 h. A soln. of 4-(dimethylaminophenylmethyl)-cyclohexylamine (Intermediate VII) (256 mg, 1.1 mmol) in THF (5 ml) was then added and the reaction mixture was stirred at RT for 3 d. Thereafter, the soln. was concentrated i. vac., the residue was taken up in NaHCO3 soln. and the mixture was extracted with MC (3×30 ml). The combined organic phases were dried with Na2SO4 and concentrated i. vac. Further purification was carried out by means of flash chromatography with CHCl3/MeOH (95:5).

Provenance & Evidence