HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 3-(Bromomethyl)isothiazolo[5,4-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-Bromosuccinamide | HCID 9834204 | — |
| Reactant | 3-Methyl[1,2]thiazolo[5,4-b]pyridine | HCID 12496975 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 3-(Bromomethyl)isothiazolo[5,4-b]pyridine | HCID 66702699 | — |
Reaction Steps
N-Bromosuccinamide (10.7 mmol) was added to a solution of 3-methylisothiazolo[5,4-b]pyridine (10.0 mmol) in carbontetrachloride (20 mL). Benzoyl peroxide (0.82 mmol) was added and the reaction mixture was heated at reflux for 48 h. The reaction mixture was filtered through Celite (ethyl acetate) and the eluent was concentrated to provide crude 3-(bromomethyl)isothiazolo[5,4-b]pyridine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106066B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-b478c96bbd39448c9af2860e121b0708 |
| Source note | uspto-grants-2012_01 |