Azobisisobutyronitrile → HCID 86611703, compound

Participants

Role	Name	HCID	Charge
Reactant	Azobisisobutyronitrile	HCID 6547	—
Reactant	N-Bromosuccinamide	HCID 9834204	—
Reactant	6-Chloro-3-methyl[1,2]thiazolo[5,4-b]pyridine	HCID 14689248	—
Solvent	Carbon Tetrachloride	HCID 5943	—
Product	HCID 86611703	HCID 86611703	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

AIBN (1.35 mmol) was added to a solution of 6-chloro-3-methylisothiazolo[5,4-b]pyridine (13.5 mmol) and N-bromosuccinamide (27.1 mmol) in carbon tetrachloride (25 mL). The reaction mixture was heated at 80° C. for 6 h, allowed to cool to rt, and the precipitated solids were removed by filtration. The filtrate was concentrated to provide crude 3-(bromomethyl)-6-chloroisothiazolo[5,4-b]pyridine as yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08106066B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-807f46e5a2574d9eb0bfcbfe23ab59e5
Source note	uspto-grants-2012_01