Hydrochloric Acid → HCID 66702053, compound

Participants

Reaction Steps

2-Cyanobenzenesulfonyl chloride (0.30 g) was added to the solution of the subtitle product of Example 3 step (0.1 g) in pyridine (1 ml) and N,N-dimethylaminopyridine (30 mg). The reaction mixture was stirred for 4 h. To the reaction mixture was added tetrabutylammonium fluoride (4 ml, 1M in THF) and stirred for 16 h. To this reaction was added aqueous hydrochloric acid (1M, 30 ml). The solvent was evaporated and the residue diluted in EtOAc (100 ml). This was washed with H2O (3×20 ml) and brine (10 ml). The organic layer was dried (MgSO4) and concentrated to yield a solid. The residue was purified by column chromatography (EtOAc/iso-hexane 7:3) followed by column chromatography (EtOAc) to yield the title compound. Yield: 30 mg.

Provenance & Evidence