Hydrochloric Acid → HCID 86639830, compound

Participants

Reaction Steps

2-(Acetylamino)-1,3-thiazole-4-sulfonyl chloride (0.19 g) was added to a solution of the subtitle product of Example 3 step (0.2 g) in pyridine (4 ml) and N,N-dimethylaminopyridine (60 mg). The reaction mixture was stirred for 4 days. To this reaction more sulfonyl chloride (0.75 g) was added and stirred for 2 days. To this reaction was added aqueous hydrochloric acid (1M, 20 ml) and THF (20 ml). This was stirred for 18 h before the solvent was evaporated and the residue diluted in EtOAc (100 ml). This was washed with H2O (3×20 ml) and brine (10 ml). The organic layer was dried (MgSO4) and concentrated to yield a solid. This material was purified by reverse phase HPLC (90% to 5% 0.02M ammonium hydroxide/acetonitrile) to yield the title compound as a solid. Yield: 20 mg.

Provenance & Evidence