1-(Bromomethyl)-3-chloro-2-fluorobenzene → 6-Amino-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4(3H)-one

HRID 424665Notes

Reaction equation

HRID 424665 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[Cl:11][C:12]1[C:13]([F:20])=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]Br>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:15][C:14]2[CH:17]=[CH:18][CH:19]=[C:12]([Cl:11])[C:13]=2[F:20])[NH:6][C:7](=[O:9])[CH:8]=1

Participants

3

Reactant 2

HCID 5228271-(Bromomethyl)-3-chloro-2-fluorobenzeneHCID 178507962HCID 178507962, compound

Product 1

HCID 1363915396-Amino-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidin-4(3H)-one

Procedure

The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (8.4 g) with 3-chloro-2-fluorobenzyl bromide (11.0 g) to afford the subtitle compound as a white solid. Yield: 14.1 g.

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-1122166607ab48cbb48e190acc823a4b
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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