(R)-(-)-2-Amino-1-propanol → HCID 66702109, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of step i) (21.2 g) in NM) (40 ml) was added (R)-alaninol (10 g) and the whole heated at 80° C. for 4 h. The reaction mixture was then partitioned between EtOAc and H2O. The organic phase was collected, dried (MgSO4) and the solvent removed to leave a pale yellow oil. This was purified by silica gel chromatography (60:40 iso-hexane/EtOAc) to afford the subtitle compound as a colourless oil. Yield: 13.9 g.

Provenance & Evidence