(1-Bromoethyl)benzene → HCID 178477348, compound

HRID 424700Notes

Reaction equation

HRID 424700 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[CH3:11][CH:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:11])[N:6]=[C:7]([OH:9])[CH:8]=1

Participants

3

Reactant 2

HCID 11454(1-Bromoethyl)benzeneHCID 178507962HCID 178507962, compound

Product 1

HCID 178477348HCID 178477348, compound

Procedure

The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (5.0 g) with □-methylbenzyl bromide (5.74 g) to afford the subtitle compound which was used directly in the subsequent step.

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-dafb46b983e548ceb9ea8c786752cd63
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Reaction notes

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