Hydrogen Peroxide → HCID 59323483, compound

Participants

Reaction Conditions

Reaction Steps

6,8-Dichloro-2-methylsulfanyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (2,4-dichloro-phenyl)-amide (Compound 3 in Scheme, 1.13 g, 2.52 mmol) in acetic acid was mixed with 30% hydrogen peroxide (0.57 g, 2 eq) and heated at 70-80° C. for 2 days upon agitation. The reactants were poured into iced water, filtered, washed with water and normal hexane and dried under vacuum. The resultant was used without further purification for next steps (yield: 1.1 g, 94%): 1H NMR (DMSO-d6) δ12.66 (bs, 1H) 8.54-8.19 (m, 4H) 7.61-7.41 (m, 2H) 3.10 (s, 3H)

Provenance & Evidence