反应详情

Process B: (3R,4S)-4-[(1S,2R)-1,2,3-Trihydroxypropyl]pyrrolidin-3-ol (0.76 g) and triethylamine (0.60 mL) were dissolved in N,N-dimethylacetamide (12 mL). While this solution was chilled in an ice water bath, benzyl chloroformate (0.58 mL) was added dropwise and the mixture was stirred for 1 hour, followed by addition of tetrahydrofuran (12 mL) and further stirring for 30 min. The insoluble material in the reaction mixture was then filtered and washed with a 1:1 mixture of N,N-dimethylacetamide and tetrahydrofuran. The filtrate and the washings were combined and concentrated under reduced pressure. The resulting residue was dissolved in a mixture of ethanol (32 mL) and water (7 mL), followed by addition of sodium periodate (1.85 g) and stirring at room temperature for 1 hour. The insoluble material in the reaction mixture was filtered and washed with ethanol. The filtrate and the washings were combined and sodium borohydride (242 mg) was added. This was followed by stirring at room temperature for 1 hour, addition of acetone (2 mL) and concentration under reduced pressure. The resulting residue was dissolved in ethyl acetate (100 mL), washed with saturated brine (2×20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluant: ethyl acetate:methanol=20:1) to give (3R,4R)-(1-benzyloxycarbonyl-4-hydroxypyrrolidin-3-yl)methanol as a milky white syrup (828 mg).

1. temperatureWhile this solution was chilled in an ice water bath
2. stirringfurther stirring for 30 min
3. filtrationThe insoluble material in the reaction mixture was then filtered
4. washwashed with a 1:1 mixture of N,N-dimethylacetamide and tetrahydrofuran
5. concentrationconcentrated under reduced pressure
6. dissolutionThe resulting residue was dissolved in a mixture of ethanol (32 mL) and water (7 mL)
7. additionfollowed by addition of sodium periodate (1.85 g)
8. stirringstirring at room temperature for 1 hour
9. filtrationThe insoluble material in the reaction mixture was filtered
10. washwashed with ethanol
11. additionsodium borohydride (242 mg) was added
12. stirringby stirring at room temperature for 1 hour
13. additionaddition of acetone (2 mL) and concentration under reduced pressure
14. dissolutionThe resulting residue was dissolved in ethyl acetate (100 mL)
15. washwashed with saturated brine (2×20 mL)
16. dry with materialdried over anhydrous sodium sulfate
17. concentrationconcentrated under reduced pressure
18. customThe resulting residue was purified by silica gel column chromatography (eluant: ethyl acetate:methanol=20:1)