HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(((3R,4S)-4-Fluoropyrrolidin-3-yl)methyl)cyclopropanamine → HCID 86609603, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(((3R,4S)-4-Fluoropyrrolidin-3-yl)methyl)cyclopropanamine | HCID 11147857 | — |
| Reactant | 6,7-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 14423854 | — |
| Product | HCID 86609603 | HCID 86609603 | 45.5% |
Reaction Steps
Using 6,7-difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (271 mg) and (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine (174 mg), the same procedure was followed as in Example 23 to give 7-[(3S,4S)-3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl]-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid as a pale yellow powder (186 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106072B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-21254b1d3eed4379860709becc216e41 |
| Source note | uspto-grants-2012_01 |