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HRID424755

反应详情

EQUATION

反应方程式

HRID 424755 的结构方程式

REACTANTS

反应物

2
结构：F[C@@H]1CNC[C@@H]1CNC1CC1
HCID11147857

未命名化合物

结构：O=C(O)c1cn([C@@H]2C[C@@H]2F)c2c(F)c(F)c(F)cc2c1=O
HCID22958360

未命名化合物

PRODUCTS

生成物

1
结构：O=C(O)c1cn([C@@H]2C[C@@H]2F)c2c(F)c(N3C[C@H](CNC4CC4)[C@H](F)C3)c(F)cc2c1=O
HCID66704881

未命名化合物

收率 52.6%

PROCEDURE

实验过程

Using 6,7,8-trifluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (301 mg) and (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine (190 mg), the same procedure was followed as in Example 23 to give 7-[(3S,4S)-3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl]-6,8-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid as pale yellow crystals (231 mg).