Ethyl Acetate → HCID 66704060, compound

Participants

Reaction Steps

To 4′-methoxy-2′-nitro-biphenyl-4-carboxylic acid methyl ester (4.00 g) suspended in ethanol (150 mL) and ethyl acetate (150 mL) is added 5% palladium on carbon (0.300 g). The reaction mixture is placed under an atmosphere of hydrogen (50 psi) and shaken on a Parr apparatus. After 18 h, the reaction mixture is degassed with nitrogen and filtered though a plug of silica gel, eluting with 700 mL ethyl acetate and 600 mL methylene chloride. The filtrate is evaporated to give 2′-amino-4′-methoxy-biphenyl-4-carboxylic acid methyl ester (3.52 g, >99%) as a white solid.

Provenance & Evidence