HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 424802Generated: October 29, 2026
Benzoyl Peroxide → 4-Bromomethyl-2-butoxy-benzoic acid methyl ester
https://huagongshe.com/reaction/424802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Butoxy-4-methyl-benzoic acid methyl ester | HCID 57443323 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-Bromomethyl-2-butoxy-benzoic acid methyl ester | HCID 57443325 | 52.4% |
Reaction Steps
A mixture of 2-butoxy-4-methyl-benzoic acid methyl ester (0.85 g, 3.8 mmol), dibenzoyl peroxide (100 mg), and NBS (0.68 g, 3.8 mmol) in CCl4 (20 mL) is heated to 70° C. overnight. The solid is filtered off and the filtrate is concentrated to a residue. The residue is purified by flash chromatography to give 4-Bromomethyl-2-butoxy-benzoic acid methyl ester as a syrup (0.6 g, 52%). LC-MS: 301.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106077B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-83a85c2af587485fa568e43b113939b9 |
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| Source note | uspto-grants-2012_01 |
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