2-Butoxy-4-formyl-benzoic Acid Methyl Ester → 2-Butoxy-4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-benzoic Acid Methyl Ester

Participants

Role	Name	HCID	Charge
Reactant	2-Butoxy-4-formyl-benzoic Acid Methyl Ester	HCID 57443319	—
Reactant	4-[(tert-butyldimethylsilyl)oxy]-N,2-dimethylaniline	HCID 66704120	—
Reactant	4-({[4-(Tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-2-methyl-benzoic acid methyl ester	HCID 66704169	—
Product	2-Butoxy-4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-benzoic Acid Methyl Ester	HCID 66704181	—

Reaction Steps

The title compound is prepared by reductive amination of [4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amine with 2-butoxy-4-formyl-benzoic acid methyl ester, essentially as described in the synthesis of 4-({[4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-phenyl]-methyl-amino}-methyl)-2-methyl-benzoic acid methyl ester using the appropriate starting material. The title compound is obtained as syrup after workup. LC-ES/MS m/e 472.3 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08106077B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-0d21f20779364c87894f4c8590f3927a
Source note	uspto-grants-2012_01