Triphenylphosphine → 3-(2-(4-(3-(2,6-Dichloro-phenyl)-5-isopropyl-3-H-(1,2,3)triazol-4ylmethyoxy)-2-methyl-phenyl)-vinyl)-benzoic acid methyl ester

Participants

Reaction Steps

To a solution of 3-(2-(4-hydroxy-2-methyl-phenyl)-vinyl)-benzoic acid methyl ester (0.09 4 g, 0.351 mmol) and (3-(2,6-dichloro-phenyl)-5-isopropyl-3H-(1,2,3)triazol-4-yl)-methanol (0.100 g, 0.351 mmol) in THF (3 mL) are added triphenylphosphine (0.184 g, 0.702 mmol) and diethyl azodicarboxylate (0.120 g, 0.720 mmol). The reaction is stirred overnight. The reaction is partitioned between ether and water. The organic layer is washed with brine and dried over sodium sulfate. The organic layers are filtered and concentrated. The crude solid is purified via flash chromatography using hexane:ethyl acetate (2:1) as eluent to give 3-(2-(4-(3-(2,6-Dichloro-phenyl)-5-isopropyl-3-H-(1,2,3)triazol-4ylmethyoxy)-2-methyl-phenyl)-vinyl)-benzoic acid methyl ester (0.04 g). ES/MS m/e (35Cl/37Cl) 535.8/538.2 (M+1).

Provenance & Evidence