Lithium Hydroxide → HCID 57652730, compound

Participants

Reaction Conditions

Reaction Steps

To an ambient temperature solution of 3-(1-{4-[3-(2,6-Dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl}-1-methyl-ethylsulfanyl)-benzoic acid methyl ester (110 mg, 0.188 mmol) in dioxane (2 mL) is added a solution of lithium hydroxide (282 μL, 0.564 mmol, 2.0N in water). The reaction is heated to 50° C. for 2 h. The reaction is concentrated and the residue is diluted with Et2O and water. The aqueous layer is adjusted to pH ˜4 and extracted with a second portion of Et2O. The combined organic layers are washed with water, dried (MgSO4), filtered, and concentrated to yield the title compound (106 mg, 99%). LC/MS (ES+): 570.0, 100.0%.

Provenance & Evidence