Sodium Hydroxide → HCID 66704199, compound

Participants

Reaction Steps

To a solution of 3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester (0.459 g, 0.825 mmol) in methyl alcohol (20 mL) is added 1 N sodium hydroxide solution (2.5 mL). The reaction is heated to mild reflux for 1 h and is cooled to room temperature. The reaction mixture is concentrated under reduced pressure. The residue is dissolved in water and the aqueous solution is acidified with 5 N hydrochloric acid solution to form a white precipitate. The solid is filtered and dried overnight under reduced pressure to give the title compound (0.395 g). ES/MS m/e 542.0 (M+1), 542.0 (M-H); HPLC purity: 95.56

Provenance & Evidence