Hydrochloric Acid → HCID 57652734, compound

Participants

Reaction Steps

To a solution of 6-{4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl}-benzo[b]thiophene-3-carboxylic acid methyl ester (0.14 g, 0.23 mmol) in a 1:1:1 mixture of THF, methanol, water (3 mL) is added LiOH (0.10 g, 2.36 mmol). The reaction is stirred for 18 h at room temperature. The reaction is adjusted to pH 3 with 1N HCl and extracted with EtOAc to yield the title compound (0.09 g, 66%). LC-ES/MS m/e 576.0 (M−1).

Provenance & Evidence