Hydrochloric Acid → HCID 24862901, compound

Participants

Reaction Steps

To a solution of 6-{4-[3-(2,6-dichloro-phenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl}-1-isopropyl-1H-indazole-3-carboxylic acid methyl ester (0.13 g, 0.21 mmol) in a 1:1:1 mixture of THF, methanol, water (4.5 mL) is added LiOH (0.09 g, 2.10 mmol). The reaction is stirred for 18 h at room temperature. The reaction is adjusted to pH 3 with 1N HCl and extracted with EtOAc to yield the title compound (0.12 g, 92%). LC-ES/MS m/e 602.0 (M−1).

Provenance & Evidence