Hydrochloric Acid → HCID 24862902, compound

Participants

Reaction Steps

To a solution of 6-{4-[5-cyclopropyl-3-(2,6-dichloro-phenyl)-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-phenyl}-1-isopropyl-1H-indazole-3-carboxylic acid methyl ester (0.18 g, 0.30 mmol) in a 1:1:1 mixture of THF, methanol, water (6.0 mL) is added LiOH (0.13 g, 3.0 mmol). The reaction is stirred for 18 h at room temperature. The reaction is adjusted to pH 3 with 1N HCl and extracted with EtOAc to yield the title compound (0.12 g, 70%). LC-ES/MS m/e 576.0 (M+1).

Provenance & Evidence