Thionyl Chloride → HCID 3934243, compound

HRID 424904Notes

Reaction equation

HRID 424904 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4](O)([C:18]([F:21])([F:20])[F:19])[C:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:7][C:6]=1[CH3:17].S(Cl)(Cl)=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3](=[O:23])[C:4](=[C:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:7]=[C:6]1[CH3:17])[C:18]([F:20])([F:21])[F:19]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 3236823HCID 3236823, compound

Product 1

HCID 3934243HCID 3934243, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a toluene solution (50 ml) of 2,5-dihydro-α-hydroxy-3-methyl-5-oxo-1-phenyl-α-(trifluoromethyl)-1H-pyrazole-4-acetic acid methyl ester (1.5 g, 4.5 mmol), thionyl chloride (2 ml, 22.5 mmol) was added and the mixture was stirred under reflux for 3 hours. After concentrating the liquid reaction mixture under reduced pressure, the title compound was obtained as a reddish brown solid (4.41 g).

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationAfter concentrating
  3. customthe liquid reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-e77051e045384204a40e09ac3d86fdf6
Source dataset
uspto-grants-2012_01
Patent number
US08106086B2

Reaction notes

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