2-Cyclohexen-1-one, 5,5-dimethyl-3-(phenylamino)- → HCID 2962082, compound

HRID 424905Notes

Reaction equation

HRID 424905 reaction equation
CO[C:3](=[O:22])[C:4](=[C:9]1[C:13](=[O:14])[N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:11]=[C:10]1[CH3:21])[C:5]([F:8])([F:7])[F:6].[CH3:23][C:24]1([CH3:38])[CH2:29][C:28](=[O:30])[CH:27]=[C:26]([NH:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:25]1>C(Cl)(Cl)Cl>[CH3:21][C:10]1[NH:11][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:13](=[O:14])[C:9]=1[C:4]1([C:5]([F:8])([F:7])[F:6])[C:27]2[C:28](=[O:30])[CH2:29][C:24]([CH3:38])([CH3:23])[CH2:25][C:26]=2[N:31]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:3]1=[O:22]

Participants

4

Reactant 2

HCID 2058962-Cyclohexen-1-one, 5,5-dimethyl-3-(phenylamino)-HCID 3934243HCID 3934243, compound

Product 1

HCID 2962082HCID 2962082, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a chloroform solution (5 ml) of 2-(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)-3,3,3-trifluoro-propanoic acid methyl ester (565 mg, 1.81 mmol), 5,5-dimethyl-3-phenylamino-2-cyclohexen-1-one (390 mg, 1.81 mmol) was added and the mixture was stirred for 14 hours. After concentrating the liquid reaction mixture under reduced pressure, the residue was purified by silica gel flash column chromatography. Thus, the title compound was obtained as a colorless solid (780 mg).

Workup

  1. concentrationAfter concentrating
  2. customthe liquid reaction mixture under reduced pressure
  3. customthe residue was purified by silica gel flash column chromatography

Sources & evidence

ORD record
ord-a5798c01fa7c49859764fd85e0eff404
Source dataset
uspto-grants-2012_01
Patent number
US08106086B2

Reaction notes

Loading…