Methyl 3,3,3-trifluoro-2-oxopropanoate → HCID 44138674, compound

HRID 424919Notes

Reaction equation

HRID 424919 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13](=[O:14])[CH:12]=[C:11]([CH3:15])[NH:10]2)=[CH:5][CH:4]=1.[F:16][C:17]([F:25])([F:24])[C:18](=[O:23])[C:19]([O:21][CH3:22])=[O:20]>C(Cl)(Cl)Cl>[CH3:22][O:21][C:19](=[O:20])[C:18]([OH:23])([C:17]([F:25])([F:24])[F:16])[C:12]1[C:13](=[O:14])[N:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[NH:10][C:11]=1[CH3:15]

Participants

4

Reactant 2

HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoateHCID 3240576HCID 3240576, compound

Product 1

HCID 44138674HCID 44138674, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
80 °C

Procedure

To a chloroform solution (5 ml) of 1-(4-methoxyphenyl)-3-methyl-5-pyrazolone (102 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (180 mg).

Workup

  1. customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record
ord-a0f38ab5e5b24a1aa34957ccf47831ab
Source dataset
uspto-grants-2012_01
Patent number
US08106086B2

Reaction notes

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