Methyl 3,3,3-trifluoro-2-oxopropanoate → HCID 44139822, compound

HRID 424923Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13](=[O:14])[CH:12]=[C:11]([CH3:15])[NH:10]2)=[CH:5][CH:4]=1)#[N:2].[F:16][C:17]([F:25])([F:24])[C:18](=[O:23])[C:19]([O:21][CH3:22])=[O:20]>C(Cl)(Cl)Cl>[CH3:22][O:21][C:19](=[O:20])[C:18]([OH:23])([C:17]([F:25])([F:24])[F:16])[C:12]1[C:13](=[O:14])[N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][CH:7]=2)[NH:10][C:11]=1[CH3:15]

Participants

Conditions

Temperature: 80 °C

Procedure

To a chloroform solution (5 ml) of 1-(4-cyanophenyl)-3-methyl-5-pyrazolone (100 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a pale yellow solid (174 mg).

Workup

customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record: ord-41b9609f6a184dd092440a53f09ebc6c
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08106086B2

Reaction notes

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